Administration of the antiviral drug alloferon (Allokin-alpha) to women suffering from CIN caused reduction in caspase-3 and caspase-9 activities, increased IL-18, and subsequent activation of IFN-γ which is an indication of the elimination of HPV (Vinogradova et al., 2021). This evidence concerns the gene IL18 and cervical squamous intraepithelial neoplasia.