BRD2 and Klinefelter syndrome: While the surgeon’s experience and laboratory expertise in dissecting and processing the testicular parenchyma can undoubtedly influence the success of sperm retrieval, many other predictors have also been investigated, such as clinical profiles, Klinefelter syndrome status, cryptorchidism, paternal age, testicular volume, and laboratory panels (FSH, inhibin B, Y-chromosome microdeletion, and surgery).21