In Covid-19 patients, each point increment of the IL-6/IL-10 ratio was associated with a 5.6 times more severe outcome.5 In children with pneumonia, the IL-6/IL-10 ratio at 9.61 determines those with severe pneumonia to those with mild disease (sensitivity 76.5% and specificity 93%).77 This evidence concerns the gene IL10 and susceptibility to pneumonia measurement.