NFKB1 and nutritional deficiency disease: NF-kB was the major transcription pathway for proinflammatory cytokine production.72 Using BMI as the parameter to determine malnutrition, subjects with severe malnutrition (BMI <16.5) had higher levels of IL-10 (8.0 ± 3.6 pg/mL) compared to those with moderate malnutrition (BMI = 16.5-18.4) (2.6 ± 4.3 pg/mL) and good nutrition (BMI ≥18.5) (2.8 ± 0.7 pg/mL) in adults,73 which was similar to the WAZ category where IL-10 was slightly increased in those underweight, and increased drastically in those severely underweight.