Maternally expressed gene 3 (MEG3), a long non-coding RNA derived from the DLK1-MEG3 locus at the chromosomal location 14q32.3, is well-established as a cancer-suppressive factor (Zink et al., 2018), which was initially recognized as the ortholog of gene trap locus 2 (Gtl2) in mice. The gene discussed is MEG3; the disease is cancer.