Patients with poor vital signs, including severe fever, tachycardia, or tachypnea, may need additional POCT, such as portable chest X-ray, neck soft tissue X-ray in cases of epiglottitis, POC venous blood gases, POC CRP, POC creatinine, POC complete blood count (CBC), and occasionally proBNP to rule out heart failure. The gene discussed is CRP; the disease is heart failure.