These may include VBG, POC creatinine to rule out acute kidney injury (AKI) associated with severe infection, POC CBC, POC troponin to rule out pericarditis, ECG, POC CRP to determine the severity of inflammation, POC proBNP to rule out heart failure secondary to severe LRTI, and POCUS for heart and lung assessment [22-24,27-29]. This evidence concerns the gene NPPB and heart failure.