In 2013, Cohen et al. [37] generated a human APP-PS1 transgenic rat model (TgF344-AD) of AD by pronuclear injections of a human APP with the Swedish mutation and a human PS1 construct with the ΔE9 mutation under the control of a mouse PrP promoter into Fischer 344 rat embryos. Here, PSEN1 is linked to Alzheimer disease.