In BRCA1 mutant breast cancer overactive Pi3K/AKT signalling in releases GSK3β mediated suppression of NRF2 nuclear translocation, supporting tumour survival (Gorrini et al., 2014), while in colorectal cancer, the regulation of GSK3β activity by the NUAK1/MYPT/PP1 complex maintains nuclear localisation of nuclear NRF2 (Port et al., 2018). Here, NFE2L2 is linked to colorectal cancer.