BCL-2 (B-cell lymphoma 2), DRP1 (dynamin-related protein 1), ER (endoplasmic reticulum), ERK (extracellular signal-regulated kinase), ETBR (endothelin B receptor), GSK3β (glycogen synthase kinase-3 beta), HMGB1 (high-mobility group box 1), HD (Huntington’s disease), IAPs (inhibitor of apoptosis proteins), MCU (mitochondrial calcium uniporter), S6K1(p70 S6 ribosomal kinase). The gene discussed is HMGB1; the disease is Huntington disease.