Notably the ADGRE5, MPZ, MHCII, and ESAM were persistently activated in the donor condition, but were shut off in DCM (Fig. 4g), whereas the PTN, JAM, EDN, and ANGPT were turned on in DCM compared with the donor condition (Fig. 4h). This evidence concerns the gene ADGRE5 and familial dilated cardiomyopathy.