SH2B1 and obesity due to melanocortin 4 receptor deficiency: However, it is noteworthy that some of these genes, such as ATP2A1, COL16A1, DCC, FOXO3, NEGR1, SH2B1, SKAP1, TUFM, and YIPF7 [11–16], have also been linked to body mass index (BMI), obesity, or both.