FBXW7 and systemic lupus erythematosus: Furthermore, in a mouse model of SLE induced by tetramethylpentadecane (TMPD), CRL1fbxw7 was found to induce apoptosis of peritoneal macrophages and neutrophils, leading to aggravated symptom in wild-type mice, as compared to myeloid cell-specific Fbxw7-depleted mice [121], further supporting the notion that neddylation-CRLs regulate the progression of SLE.