PTPN11 and neoplasm: Neddylation deactivates SHP2, facilitating the ability of macrophages to engulf opsonized tumor cells and enhances the effectiveness of in vivo immunotherapy when combined, whereas SENP8 maintains SHP2 in a deneddylation status to activate and recruit it toward SIRPα, which, in turn, suppresses macrophage phagocytosis [91].