TRAF6 and osteoporosis: Mechanistically, UBA3-induced neddylation is actively involved in activation of the TRAF6-TAK1-NFATc1 signaling pathway-induced RANKL during osteoporosis and osteoclast differentiation, and TRAF6 neddylation at Lys124 is necessary for NF-κB activation induced by IL-17A in CIA [49,50].