For instance, MLN4924 induces apoptosis in CLL B cells and reduces drug resistance by causing accumulation of (a) phospho-IκBα through CRL inactivation, blocking the nuclear translocation of p65 and p52 and, thus, inhibiting both the canonical and non-canonical NF-κB pathways; and (b) NOXA and BIM, eventually leading to apoptotic cell death [110]. This evidence concerns the gene RELA and B-cell chronic lymphocytic leukemia.