While there is no study in the literature reporting a direct regulation of NEDD8 or neddylation enzymes on the development of AIDs, CRLs, whose activity was activated by neddylation, have been found to play an important role in several AIDs, such as psoriasis, type I diabetes, systemic lupus erythematosus (SLE), multiple sclerosis, and rheumatoid arthritis (RA) [35]. This evidence concerns the gene NEDD8 and systemic lupus erythematosus.