Finally, in an LPS-induced acute kidney injury (AKI) model, MLN4924 attenuates renal inflammation by inactivating CRL1 and subsequent NFκB inactivation, leading to reduced production of pro-inflammatory cytokines (TNF-α, IL-6, and IL-1β) upon LPS stimulation in renal tubular cells [130]. The gene discussed is IL6; the disease is acute kidney injury.