This in seen in the case of the biomarker Prostate Specific Antigen (PSA), whereas “at best PSA screening modestly decreased prostate cancer-related mortality.”11 Similarly, when considering breast cancer, manual palpation,12 mammography,13–15 and ultrasound,16 all have demonstrated limitations with life altering consequences. The gene discussed is KLK3; the disease is Familial prostate cancer.