VWF and ischemic stroke: Albeit the authors did not assess the role of PITTs in experimental stroke, it is tempting to speculate that PITTs might be involved in VWF-dependent immune cell recruitment following ischemic stroke, as post-ischemic endothelial cells expose VWF[106], and previous studies have shown that platelet αIIbβ3 can modulate neutrophil activities [107,108].