We first used TRlnc 33 and LncSEA34 to explore the mechanism of the transcriptional regulation of PCBP1-AS1 in lung adenocarcinoma and its possible biological role, the results showed that PCBP1-AS1 mainly functioned through RNA-RNA interaction and RNA-protein interaction, and mainly regulated tumor immunity (Figure S2). The gene discussed is PTGDR; the disease is lung adenocarcinoma.