The prognostic stratification capacity of AFP levels has been substantiated through numerous studies, leading to its incorporation as a pivotal variable in esteemed HCC prognostic scoring systems, such as the Cancer of the Liver Italian Program score (17), Chinese University Prognostic Index (18), Metroticket 2.0 model (15), and French AFP model (16). This evidence concerns the gene AFP and hepatocellular carcinoma.