CD4 and melanoma: For example, in a mouse model of melanoma induced by intradermal injection of B16 cells, the depletion of nociceptors has been shown to increase the presence of immune cells with anti-tumoral properties, including CD4+ and CD8+ T cells, while reducing the abundance of pro-tumoral cells like regulatory T cells (Treg), tumor-associated macrophages (TAM), and neutrophils (109, 206).