In a melanoma mouse model induced by subcutaneous injection of B16 cells, activating nociceptors has been found to enhance the recruitment of NK, CD4+, and CD8+ T cells, which exhibit a less exhausted phenotype with reduced PD1 and cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) expression (200). The gene discussed is CTLA4; the disease is melanoma.