It may also represent a new option for endocrine-resistant hormone receptor-positive/HER2-negative metastatic BC, since it has recently shown a longer PFS and a statistically significant OS compared to standard chemotherapy (capecitabine, eribulin, vinorelbine or gemcitabine) after CDK4/6 inhibitors and 2 to 4 previous lines of chemotherapy (26). The gene discussed is NR4A1; the disease is breast cancer.