There are discrepancies between cohorts on the relative frequency of each autoantigen; Liu and colleagues assessed for the presence of autoantigens in a US IgG4-RD cohort and found 7% positivity for laminin 511-E8, 10% for prohibitin, 12% for annexin A11 and 28% for galectin-3 (118). The gene discussed is LGALS3; the disease is immunoglobulin G4-related sclerosing disease.