NOS2 and neoplasm: This process necessitates the activation of STAT3 by cyclic adenosine monophosphate (cAMP)-response element-binding protein (CREB)-binding protein (CBP)/p300.134 STAT3 not only promotes tumor cell proliferation, survival, neovascularization, and metastasis but also exerts an inhibitory effect on anticancer immunity.125 IFN-γ and TNFα promote the inducible nitric oxide synthase (iNos) gene promoter’s response to NF-κB through activation of JAK-STAT signaling in muscle fibroblasts recruitment, thereby activating the iNOS/nitric oxide (NO) pathway and inducing muscle atrophy.135