NFKB1 and autoimmune disease: Due to the key regulatory role of NF-κB signaling in immune and inflammatory responses, its dysregulation has been strongly associated with a variety of human diseases, including cancer, inflammatory diseases, autoimmune disorders, viral infections, and infectious shock.81,189,193 During inflammation, the NF-κB signaling is hyperactivated, leading to the abundant expression of inflammation-associated genes.