In a mouse model of rheumatoid arthritis, treatment with KIC-0101 significantly improves cartilage damage and inflammation.591 Additionally, researchers have discovered that Perillyl alcohol (POH) effectively ameliorates arthritis in rats by modulating the TLR4/NF-κB signaling pathway.592 The current research has identified several novel targets for treating osteoarthritis (OA) through the NF-κB pathway. The gene discussed is NFKB1; the disease is arthritic joint disease.