Hyperglycemic state in diabetic patients leads to abnormal bone metabolism, causing peri-implantitis and alveolar bone defects in the implant area, and activation of NF-κB signaling as a mechanism to maintain a long-term inflammatory state.437 Inhibition of NF-κB signaling activation in stem cells indirectly modulates macrophage polarization toward M1, which can restore immunoregulatory capacity and reduce local inflammation.438. Here, NFKB1 is linked to Peri-Implantitis.