Inhibition of NF-κB signaling in CAFs abolished its tumor-promoting effects, suggesting the critical role of NF-κB in CAFs-mediated protumor effects.262 A single-cell RNA sequencing analysis suggested that the pattern recognition receptor Mincle was highly expressed in TAM, largely induced in bone marrow-derived macrophages by cancer cells to promote tumor development. Here, NFKB1 is linked to cancer.