NFKB1 and long COVID-19: This cascade of events contributes to the cytokine storm observed in severe cases, leading to tissue damage and worsening clinical outcomes.476,477 The role of NF-κB in the long-lasting stage of COVID-19 infections involves persistent inflammatory responses, potential tissue damage, and complications leading to prolonged symptoms or post-acute sequelae of SARS-CoV-2 infection (PASC).