El-Nikhely et al. reported the bidirectional role of metastasis-associated protein 2 (MTA2) in IKK2/ NF-κB-driven lung cancer progression.280 They found that metastasis-associated protein 2 (MTA2)/nucleosome remodeling and deacetylase (NuRD) corepressor complex can downregulate NF-κB signaling and inhibit tumor growth in an IKK2-independent manner. This evidence concerns the gene NFKB1 and lung cancer.