RELA and periodontitis: Periodontitis is characterized by the pathological loss of periodontal ligament and alveolar bone.365 The disease involves complex interactions between specific bacterial pathogens and destructive immune responses.365,366 In a model of periodontitis, a single intra-gingival injection of LPS results in the significant expression of NF-κB p65 and pro-inflammatory cytokines in gingival tissues after 14 h.