Among them, the prominent role of NF-κB signaling in different stages of atherosclerosis is established.391 In fact, NF-κB signaling is a key element in the common pathogenesis of several atherosclerosis-associated diseases, including abdominal aortic aneurysm, peripheral artery disease, cerebrovascular disease and coronary artery disease.392–395 Endothelial cells (ECs) dysfunction plays a key role in the initiation of atherosclerosis. This evidence concerns the gene NFKB1 and coronary artery disorder.