These genes encompass antimicrobial peptides, cytokines, chemokines, stress response proteins, and anti-apoptotic proteins, among others.79 Persistent activation of the NF-κB pathway is frequently implicated in inflammatory conditions like rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis (MS), and asthma.214 Gaining deeper insights into the modulation of the NF-κB pathway holds the potential to establish targeted therapies for inflammatory diseases. The gene discussed is NFKB1; the disease is inflammatory bowel disease.