NFKB1 and cancer: Although the targets of NF-κB in tumor cells may be similar to those in normal cells, the negative feedback control is dysregulated in cancers, leading to sustained inhibition or activation of target genes.251 The effects of aberrant NF-κB include activating proto-oncogenes and genes involved in cell-cycle to promote tumor proliferation, inhibiting apoptosis to support the survival of cancer cells, regulating genes related to cell adhesion to facilitate metastasis.