NFKB1 and Insulin resistance: The 10th edition of the Global Diabetes Map reveals that approximately 537 million adults (20–79 years old) worldwide will be afflicted with diabetes in 2021, accounting for ~10.5% of the global population within this age range, and this number is projected to escalate to 643 million in 2030.417 Insulin resistance, type 2 diabetes, and its complications are considered chronic inflammatory diseases, and NF-κB signaling is a key pathway linking inflammation and metabolism.182,418,419