PIK3CA and hepatocellular carcinoma: In hepatitis B Virus (HBV)-related hepatocellular carcinoma (HCC), hepatitis B protein X (HBx) induces aerobic glycolysis and produces a large amount of lactic acid through NF-κB/hexokinase 2 (HK2) signaling, which further activates PI3K/AKT signaling and improves the malignant proliferation ability of HCC cells.111 Somatostatin receptor subtype 2 (sst2) inhibits KRAS-activated PI3K signaling.