For example, Herkenne et al. reported that mitochondria-shaping protein OPA1 is required in an NF-κB-dependent signaling essential for developmental and tumor angiogenesis, which revealed the role of NF-κB in mitochondrial dynamics during angiogenesis.272 It is noteworthy that matrix metalloproteinases (MMPs) are also targets of NF-κB, which promote angiogenesis and metastasis in different microenvironments.273. Here, NFKB1 is linked to neoplasm.