TBK1 and obesity due to melanocortin 4 receptor deficiency: TBK1 knockdown and NOD-like receptors family pyrin domain containing 12 (NLRP12, an inhibitory immune receptor) attenuate inflammasome activation and obesity by inhibiting NF-κB signaling.424,455 It has also been found that circadian clock impairment in adipose tissue due to NF-κB signaling may be a cause of obesity and its complications.456