It has been reported that this drug can prevent the dissociation of NF-κB from the NF-κB/IκB complex, thereby preventing the translocation of NF-κB from the cytoplasm to the nucleus and inhibiting the transcription of COX-2.487 Furthermore, sodium salicylate induces a shift from a proliferative to an apoptotic phenotype in human leukemia cells by inhibiting the NF-κB response and restoring TNF-induced apoptosis.488. Here, NFKB1 is linked to leukemia.