VEGFR-3 forms a negative feedback loop that inhibits TLR4-NF-κB-mediated inflammatory responses, thereby reducing the occurrence of sepsis or endotoxic shock resulting from bacterial infections.375 Inhibition of NF-κB activation has been shown to reduce acute inflammatory processes and organ dysfunction.374 These findings highlight the potential effectiveness of targeting NF-κB for the treatment of sepsis. Here, TLR4 is linked to Sepsis.