Initially, researchers discovered that NF-κB potentially contributes to the pathogenesis of acquired immune deficiency syndrome (AIDS) by synergizing with and stimulating the transcription of human immunodeficiency virus (HIV).194 Research on p50-deficient mice has demonstrated the crucial involvement of NF-κB in both specific and non-specific immune responses, and although there is no evidence for the involvement of NF-κB in the developmental process.195. Here, CD40 is linked to AIDS.