NFKB1 and IgA glomerulonephritis: These immune complexes deposit in various parts of the kidney, leading to pathological damage.383 IgA nephropathy, the most common form of glomerulonephritis, involves the binding of IgA to Fcα receptors on mesangial cells, which activates NF-κB and contributes to the induction of chemokines MCP-1 and IL-8.384,385 NF-κB also plays a role in lupus nephritis.