Mechanistically, aspirin reduces the migration, invasion, and metastasis of osteosarcoma cells through the modulation of the NF-κB pathway.482 Hydrogen sulfide-releasing aspirin (HS-ASA), a novel derivative of aspirin, inhibits the growth of MDA-MB-231 breast cancer cells by downregulating the NF-κB pathway, inducing cell cycle arrest, and promoting apoptosis. This evidence concerns the gene NFKB1 and breast cancer.