NFKB1 and breast cancer: It has been found in a study that enrichment of Mycobacterium avium upregulated intratumoral LPS, which subsequently promoted prostate cancer progression and docetaxel resistance through activation of the NF-κB-IL6-STAT3 signaling axis.295 Tamoxifen is a commonly used endocrine medication for breast cancer, and the ensuing problem of drug resistance should not be ignored.