Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by dysregulation of B cells and T cells, leading to the activation of polyclonal B cells and the production of autoantibodies.345 Nuclear NF-κB plays a significant role in the pathogenesis of SLE by promoting the proliferation of T cells and B cells346–348 (Fig. 4f). This evidence concerns the gene NFKB1 and systemic lupus erythematosus.