THBS2 and Aortic dissection: Furthermore, Sanger sequencing demonstrated that the THBS2 variant segregated within the studied family consistent with fully-penetrant dominant inheritance (Fig. 2A); although a DNA sample and detailed phenotyping were not available for the deceased individual I:1, I:2 was shown not harbor the pathogenic variant, suggesting that the THBS2 variant was likely inherited from I:1, who died of aortic dissection.