PGAM5 and osteoarthritis: To conclude, PGAM5 serves as a novel factor of regulating macrophage polarization in osteoarthritis via dephosphorylating DVL2, resulting in increased activity of GSK3β and degradation of β-catenin,27 which disables the translocation of β-catenin into nucleus to bind to promotors for downstream signaling pathways, further contributes to increased M1 and decreased M2 phenotypes via specific signals.