PGAM5 and osteoarthritis: To address the role of macrophage PGAM5 in osteoarthritis, we generated Pgam5fl/fl -lyz2-Cre (Pgam5 cKO) mice, by crossing Pgam5fl/fl mice with transgenic mice that carried lysozyme (Lyz2) proximal promoter - mediated Cre recombinase, which specifically ablates PGAM5 from macrophages.