To conclude, PGAM5 serves as a novel factor of regulating macrophage polarization in osteoarthritis via dephosphorylating DVL2, resulting in increased activity of GSK3β and degradation of β-catenin,27 which disables the translocation of β-catenin into nucleus to bind to promotors for downstream signaling pathways, further contributes to increased M1 and decreased M2 phenotypes via specific signals. This evidence concerns the gene GSK3B and osteoarthritis.