We discovered a nonlinear relationship between HbA1c and 3-month adverse clinical outcomes in AIS patients with DM using the GAM and smooth curve fitting (adjusting for age, smoking status, sex, TG, BMI, HGB, HDL-C, ALB, C-reactive protein, LDL-C, Scr, previous stroke or TIA, CHD, hypertension, stroke etiology, and NIHSS score) (Fig. 2). The gene discussed is CRP; the disease is coronary artery disorder.