EGLN3 and cholangiocarcinoma: In cholangiocarcinoma (CCA), the tumor suppressor KIF1Bβ induced apoptosis and was up-regulated by Egl nine homolog 3 (EGLN3), and ubiquitin-specific peptidase 9X (USP9X) acted to de-ubiquitinate and stabilize EGLN3 thereby accelerating this process.