By uniting the IHC staining results of 90 paired HCC samples and their corresponding pathological features, it was further demonstrated that patients with low CENP-E expression were usually accompanied by poor OS, large tumor size, late TNM stage, as well as increased metastasis, suggesting the latent protective role of CENP-E in the development of HCC [90]. Here, CENPE is linked to hepatocellular carcinoma.