Except for KIF2C, another family member KIF2A, has been shown to be negatively regulated by miR-424-5p [110], and the protein was also proved to facilitate viability and motility of HCC cells, as well as tumor angiogenesis via Notch 1 signaling axis, in which KIF2A could interact with Notch 1 and positively induce its expression, thereby enhancing the downstream signaling transduction and HCC promotion [111]. The gene discussed is NOTCH1; the disease is hepatocellular carcinoma.