Similarly, by analyzing the mRNA expression of Eg5 in 26 HCC specimens and paired para-cancerous samples, as well as the relative protein expression in 156 HCC specimens, it was also revealed that Eg5 was obviously elevated in tumors, and patients’ OS, liver cirrhosis, and TNM stage were tightly correlated with the expression of Eg5, which further enhanced the predictive performance of Eg5 in prognosis evaluation of patients with HCC [122]. Here, KIF11 is linked to cirrhosis of liver.