PIK3CA and neoplasm: Except for the regulatory roles of kinesin-3 family members in Akt signaling, KIF4A (kinesin-4 family member) was also confirmed to protect tumor cells from apoptosis via facilitating PI3K/Akt signaling, reflected by the up-regulation of p-Akt levels, as well as corresponding changes of several apoptosis biomarkers when KIF4A was overexpressed, including decreased Bax, cleaved-caspase-3/7/9, cleaved-PARP, and increased Bcl2, while these promoting effects could be reversed by KIF4A depletion [66].