KIF18A and cholangiocarcinoma: In CCA, based on the proteomic analysis with plasma samples from Opisthorchis viverrini (OV) and N-nitrosodimethylamine induced hamster CCA models, it was indicated that the expression of KIF18A was drastically up-regulated in CCA models compared to the normal control, indicating the potential significance of KIF18A in the early diagnosis of CCA, while the above findings were acquired mainly according to the animal models that large-scale clinical trials remained needed to further verify the diagnostic and prognostic meaning of KIF18A in patients with CCA [136].