Theoretically, a potential interaction between KIF2C and Tre2-Bub2-Cdc16 (TBC) 1 domain family member 7 (TBC1D7) was identified by liquid chromatograph mass spectrometry (LC-MS), and this physical association was further validated via the exogenous and endogenous co-IP, substantiating that KIF2C and TBC1D7 could constitute a compound automatically and exert an oncogenic efficiency in HCC. The gene discussed is TBC1D7; the disease is hepatocellular carcinoma.