AKT1 and hepatocellular carcinoma: First for the kinesin-2 family shown in Fig. 2A, there was only one study that reported the promotive role of KIF3B in HCC pathogenesis, KIF3B knockdown could drastically restrain proliferation and stimulate apoptosis of cancer cells, and this effect was probably correlated with the Akt signaling given the result that the reduction of p-Akt expression following KIF3B-depletion [49].