Unexpectedly, the radios of KIF1B mRNA in 68 HCC and paired normal tissues were demonstrated to be associated with OS and DFS, that down-regulated KIF1B mRNA radios in HCC pairs (higher KIF1B expression in peritumoral samples than in tumors) indicated a worse survival outcome, while there was no obvious correlation with most clinicopathological features in terms of individual KIF1B mRNA expressions. Here, KIF1B is linked to hepatocellular carcinoma.