In addition, Ni et al. found that inhibition of HIF-1α released the antitumor activity of NK cells by establishing single-cell RNA sequencing in mice with conditional targeting deficiency of HIF-1α in NK cells, as evidenced by the inhibition of tumor growth, activation of markers, elevation of expression of the effector molecule IFN-γ, and enrichment of the NF-κB pathway in tumor-infiltrating NK cells [29]. The gene discussed is IFNG; the disease is neoplasm.