CD274 and neoplasm: Although GDC-0919 alone or in combination with anti-PDL1 neither show antitumor activity nor affect tumor immune cell infiltration, GDC-0919 was found to induce downregulation of granzyme expression, as well as upregulation of inhibin subunit beta A (inhba) and E3 Ubiquitin ligase Dtx4 [107].