In conclusion, our findings demonstrate a notable shift in allele frequencies within the CYP1A2-rs17861162 SNP, from the prevalent C allele to the disease-associated G allele, resulting in an 11% increase, as well as a substantial 28.5% increase in the T allele of the ADSL-rs3788579 SNP among female breast cancer patients in North-West Iran when compared to healthy controls. This evidence concerns the gene CYP1A2 and breast carcinoma.