Five days post infection with rAd-MitoScaI, C57WT and Mgme1KW mice both had a marked decrease in mtDNA levels (Nd1 and D-Loop), nearly to 0%, while Mgme1 KK kept around 30% of their baseline mtDNA levels (Fig. 1, D and F) which fell in line with the results seen in cultured cells. Here, MGME1 is linked to infection.