In CRC, sequential loss of function of APC (a core inhibitor of Wnt/β-catenin signaling) and TP53 is common during adenoma-to-carcinoma progression (27), and β-catenin signaling has been shown to induce FOXQ1 expression in CRC cells (8) (Fig. S3, A and B). Here, APC is linked to colorectal carcinoma.