We in addition repeated these experiments in HeLa (cervical cancer) cells with wildtype p53 and obtained consistent results (Fig. S2, I–M); p53 depletion resulted in significantly increased FOXQ1 promoter activity, mRNA, and protein levels, whereas p53 overexpression caused repression of FOXQ1 promoter activity and mRNA levels. The gene discussed is TP53; the disease is cervical carcinoma.