We select six representative genes from CancerMine, which include three most frequently reported genes in the context of acute myeloid leukemia (AML), KMT2A, FLT3, and MLLT3, as well as three genes that are least reported in this specific cancer, namely ZFP36L2, ZIC2, and ZNF582. The gene discussed is ZIC2; the disease is acute myeloid leukemia.