TNF-α was also found to promote formation of the p53-p65 complex and its translocation to the nucleus, suggesting that osimertinib induces TNF-α production through a positive feedback mechanism mediated by the TNF-α–NF-κB signaling pathway in NSCLC cells with TP53-GOF mutations (Fig. 8). The gene discussed is RELA; the disease is non-small cell lung carcinoma.