The pattern of mTORC1 signalling strongly correlated with expression of erythropoiesis and myelopoiesis markers, with hypoxanthine reversing enhanced levels of GlyA and CD71 in CML cells (K562 and JURL-MK1) and CD11b in AML cells (THP1 and MOLM13) (Fig. 4b and Supplementary Fig. 5c, d). Here, ITGAM is linked to acute myeloid leukemia.