In fact, increased levels of IL-22 and HBD-2 in GCF, as well as, a positive correlation between both proteins with periodontal clinical parameters; plaque index (PI), gingival index (GI), probing deep (PD), and clinical attachment level (CAL) have been reported in subjects with gingivitis and chronic periodontitis, however, to distinguish between both conditions, subjects with chronic periodontitis presented a significant increase of IL-22 and HBD-2 levels in GCF compared to subjects with gingivitis [69]. This evidence concerns the gene IL22 and periodontitis.