In addition, IL-17 acts synergistically with TNF-α and IL-1 to induce the release of receptor activator of NF-κB ligand (RANKL) that binds with its receptor RANK on the surface of preosteoclasts, producing osteoclastogenesis and initiating the process of bone destruction in periodontitis [26, 27]. The gene discussed is IL1B; the disease is periodontitis.