The results of our study showed an increase in the levels of IL-23/IL-17 axis in GCF of individuals with gingivitis compared to healthy controls, likewise the most important finding of this study showed that the mean level of IL-23/IL-17 axis in GCF of subjects with chronic periodontitis significantly increased compared to gingivitis and periodontally healthy individuals. The gene discussed is IL17A; the disease is periodontitis.