Thirdly, we analysed a cell-based model of AD, generated by treating SHSY-5Y cells with both AICD (amyloid precursor protein intracellular domain) and beta-Amyloid-[1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40,41,42] or Aβ1–42 protein fragment (referred as Aβ) for 48 h [47]. The gene discussed is APP; the disease is Alzheimer disease.