CD274 and neoplasm: Moreover, we detected that in tumor tissues, the proportion of M1-like macrophages was significantly increased in the shPinX1 + Anti-PD-L1 + IR group compared to either the Anti-PD-L1 + IR group (p < 0.0001) or the shPinX1 + IR group (p < 0.0001), whereas the proportion of M2-like macrophages was markedly decreased in the shPinX1 + Anti-PD-L1 + IR group compared to the Anti-PD-L1 + IR group (p = 0.0153), which suggests that shPinX1 combined with radioimmunotherapy may be involved in the reprogramming of macrophages from M2-type to M1-type (Fig. 4H–J).