In addition, the percentage of exhausted CD8+T cells in the shPinX1 combined with radioimmunotherapy group was much lower in compared with the IR + anti-PD-L1 group(p = 0.0481) or IR + shPinX1 group(p = 0.0212) in tumor tissues(Fig. 4F, G). The gene discussed is CD274; the disease is neoplasm.