UBQLN1 and poikiloderma with neutropenia: In validation cohort 2, anti-UBQLN1, 3 traditional biomarkers (CEA, CYFRA211 and CA125) and 10 nodular characteristics of CT (number, diameter, cavity, spicule sign, vascular notch sign, lobulation sign, spines, pleural indentation, mediastinal lymph node enlargement and calcification) were employed to construct model for the differentiation of PN patients based on logistic regression analysis.