Moreover, we studied transgenic mice systemically overexpressing human KST (hKST-TG) and wild type littermate control mice (WT) under normal chow (NCD) and high-fat diet (HFD) conditions.<h4>Results</h4>In sWAT of people with overweight to obesity, KST mRNA increased after diet-induced weight loss. Here, SERPINA4 is linked to obesity due to melanocortin 4 receptor deficiency.