ANGPTL4 and peritonitis: Previously, it was observed that genetic and antibody-mediated whole-body inactivation of ANGPTL4 in mice fed a diet rich in saturated fatty acids elicits severe and ultimately lethal chylous ascites and peritonitis, which is preceded by enlarged mesenteric lymph nodes, the presence of lipid-filled giant cells, and a massive acute phase response (30, 74).