RUNX2 and cancer: Concurrently, elevated levels of RUNX2 in cervical cancer were found to be associated with decreased miR-218-5p expression, and this high expression of RUNX2 positively regulated cervical cancer cell proliferation [67].Wang et al. found that MRE11 plays a pro-cancer role in oral cancer through the RUNX2/CXCR4/AKT/FOXA2 signaling axis, and both MRE1 and RUNX2 have been shown to be highly expressed in oral cancer samples [68].