Moreover, RNCR3 overexpression blocks the inhibitory effect of miR-1301-3p on the proliferation and invasion of colorectal cancer cells, while upregulating AKT1 to promote colorectal cancer progression [162].Overall, RUNX1 plays a significant role in modulating metastasis through its interactions with multiple signaling pathways, thus representing a complex but crucial factor in the progression of diverse malignancies. The gene discussed is AKT1; the disease is colorectal cancer.