ZIC2 and nonpapillary renal cell carcinoma: In ccRCC, RUNX2 is up-regulated by ZIC2 and it enhances the proliferation and migration of ccRCC cells by transcriptionally suppressing the tumor suppressor, NOLC1, and dysregulation of ZIC2/RUNX2/NOLC1 signaling promotes ccRCC metastasis [73].