In line with its recognized role as a suppressive modulator of tumor stemness, Jiang et al. substantiated that in LUAD, RUNX3 is directly downregulated by miR-1275, resulting in the activation of Wnt/β-catenin and Notch signaling pathways; this mechanism consequently enhances the stem-like properties of LUAD cells, thereby promoting tumorigenesis, recurrence, and metastasis [135]. The gene discussed is RUNX3; the disease is neoplasm.