In epithelial ovarian cancer (EOC), RUNX2 promotes cell proliferation and invasion by regulating PKD2 and PKD3, thereby activating the MAPK/ERK1/2 signaling pathway, a finding that is further corroborated by Tong et al. who also confirmed elevated RUNX2 expression in EOC tissues and cells [70, 71]. This evidence concerns the gene RUNX2 and ovarian carcinoma.