TF and osteoarthritis: Future studies aiming to characterise PTMs in primary cells, which can be challenging to collect in sufficient numbers required for ChIP-Seq, may choose to opt for CUT&RUN (Cleavage Under Targets and Release Under Nuclease) [59] (Table 1). Using CUT&RUN, which requires as few as 10,000 cells per assay, Sarkar et al. have recently investigated binding sites of the TF STAT3 in human foetal, adult, and osteoarthritis chondrocytes [64].