Furthermore, the authors functionally validated these regions in driving the inflammatory response using CRISPR-Cas9 to delete an IL-1-induced open chromatin region within MMP13, encoding matrix metalloproteinase-13 (a well-characterised initiator of cartilage catabolism) from the genome of SW1353 immortalised chondrosarcoma cells. This evidence concerns the gene MMP13 and chondrosarcoma.