Dysregulated macroautophagy is implicated in neurodegeneration in ALS [149] and ALS-associated variants in C9ORF72, SOD1, TARDBP, TBK1, FUS, FIG4, OPTN, UBLN2, SQSTM1, CHMP2B, ALS2 dysregulate macroautophagy [150]. This evidence concerns the gene ALS2 and amyotrophic lateral sclerosis.