Contrastingly, in a study of individuals with type 2 diabetes (n = 1,066, Edinburgh Type 2 Diabetes Study), increased arteriolar tortuosity was found to have a significant relationship with stroke risk in models adjusted for cardiovascular risk factors and diabetic retinopathy (HR 1.31, 95% CI 1.01–1.68, p = 0.04) although this significance was attenuated when CRP was considered (p = 0.07) [32]. The gene discussed is CRP; the disease is type 2 diabetes mellitus.