IL6 and neoplasm: On the other hand, theoretically, ablation of large intrahepatic tumors can cause high level of inflammation, which is consistent with our observation that cryoablation of tumor  > 3 cm lead to greater increases in both serum level of NLR (7.21 vs 3.59) and IL-6 (15.40 pg/ml vs 8.62 pg/ml) after treatment as compared with cryoablation of tumor  ≤ 3 cm.