With a hope of transferring the migration pattern of macrophages into CAR-T cells, we generated lentivirus encoding an anti-CLDN18.2 CAR and a mouse version of CXCR2 (CXCR2 CAR) and evaluated the anti-tumor potential of the CAR-T cells both in vitro and in vivo. Here, CXCR2 is linked to neoplasm.