However, with the introduction of migration resistance, the cytotoxic capability of CXCR2 CAR-T cells was significantly superior to that of CAR-T cells (Fig. 2D, E).To further assess the cytotoxic effectiveness of CXCR2 CAR-T cells against tumor cells, we developed a humanized organoid model and substituted mouse CXCR2 with human CXCR2. This evidence concerns the gene CXCR2 and neoplasm.