AQP4 and Parkinson disease: In A53T mice of the PD model, the accumulation of perivascular α-synuclein (α-Syn) and compromised AQP4 polarization were observed in the substantia nigra; moreover, the disruption of brain lymphatic drainage exacerbated α-Syn accumulation, glial activation, dopaminergic neuron loss, and motor impairments in these mice[46].