VEGFC and Alzheimer disease: An increasing number of experimental animal studies have demonstrated that different forms of VEGFC supplements, such as a recombinant VEGFC protein[75], AAV1-CMV-mVEGF-C156S[34], VEGFC peptide[34] or VEGFC mRNA[111], significantly increase meningeal lymphatic vessel coverage and subsequently improve brain lymphatic drainage functions, thus playing important roles in brain tumors[111], traumatic brain injury[112], AD[42,75], and other diseases.