AQP4 and brain injury: Using an AQP4 agonist (cyanamide, CYA) and an AQP4 inhibitor (TGN-020), studies have suggested that minocycline treatment for traumatic brain injury preserves blood-brain barrier integrity by decreasing the AQP4 level and restoring the localization of the astrocyte AQP4, which reveals the importance of AQP4 in the amelioration of brain injury by minocycline[102].