The results of CFG rank revealed that two genes (GABRG2, GNG3) in EC region, three genes (GABRG2, GNG3, SH3GL2) in HP region, two genes (AGT, CXCL16) in TC region and 1 gene in FC region (C3) were related with AD, among which GABRG2, CXCL16 and C3 were strongly correlated with Aβ and tau (Table S3). The gene discussed is SH3GL2; the disease is Alzheimer disease.