We identified four lncRNAs (XIST, NEAT1, KCNQ1OT1 and HCG18) and four miRNAs (hsa‐let‐7c‐5p, hsa‐miR‐107, hsa‐miR‐129‐2‐3p and hsa‐miR‐214‐3p) were preliminarily identified as potential biomarkers for early AD, competitively regulating Atp6v0b, Atp6v1e1 Atp6v1f and Syt1. Here, XIST is linked to Alzheimer disease.