Considering that some of the signalling pathways that crosstalk with the PI3K‐Akt‐mTOR pathway activated by HMMR have been reported, including EGFR/AKT/ERK,70 ROK‐PI3K71 and the evidence of mTOR‐SRF axis regulates HMMR expression in human prostate cancer cells.72 This evidence concerns the gene EGFR and Familial prostate cancer.