Considering that some of the signalling pathways that crosstalk with the PI3K‐Akt‐mTOR pathway activated by HMMR have been reported, including EGFR/AKT/ERK,70 ROK‐PI3K71 and the evidence of mTOR‐SRF axis regulates HMMR expression in human prostate cancer cells.72 Here, SRF is linked to prostate carcinoma.