Our observation that DIO1 expression is disturbed is supported by previous reports in different types of cancer, with a similar reduced expression in papillary thyroid carcinoma [25, 26, 27, 28, 29], thyroid adenoma [30], lung cancer [31], hepatic cancer [32, 33], and clear cell renal cell carcinoma [34, 35, 36, 37, 38]. This evidence concerns the gene DIO1 and Thyroid adenoma.