Further analysis revealed that its downstream receptor, IL-11RA, is predominantly distributed and also significantly overexpressed in the tumor cells themselves.Specifically, our single-cell secretion analysis delineated a mechanism whereby autocrine IL-11 signalling activates the JAK1/STAT4 pathway, leading to phosphorylated STAT4 (pSTAT4) nuclear translocation. Here, STAT4 is linked to neoplasm.