ERBB3 and familial pancreatic carcinoma: Bourillon et al. found that HER3 antibody‒drug conjugates (HER3 ADCs) based on MMAE were effectively internalized by tumor cells, increased the proportion of cells arrested in G2/M phase, which is the most radiation-sensitive phase in the cell cycle, and promoted programmed cell death in irradiated HER3-positive pancreatic cancer cells.