CEACAM5 and non-small cell lung carcinoma: In the first clinical study, which included 92 patients with advanced NSCLC for whom previous treatments had failed, SAR408701 achieved ORRs of only 7.1% in the moderate CEACAM5 expression group and 20.3% in the high CEACAM5 expression group, with a median DOR of 5.6 months.