MVs of ALS patients have been identified to be enriched by the accumulation of ALS-related proteins, namely SOD1, TDP-43, pTDP-43, and FUS [16], suggesting EV-mediated prion-like propagation of ALS disease [19], these mutant proteins retrieved in EVs are delivered across the brain cells and spread the disease (Table 1). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.