IFNAR1 and central nervous system cancer: Although IFNAR1 depletion has been recently described as associated with decreased motility and invasion of glioma cells, leading to improved survival rates [41], many studies demonstrated the role of this receptor in restoring the immunosuppressive microenvironment in GBM, driven by the constitutive absence or downregulation of IFNAR, and in facilitating the infiltration and activation of immune cells within the TME [42, 43].