CD4 and glioblastoma: Indeed, genes that were upregulated in GBM vs MM-BM enriched for the biological processes related to: (i) a negative regulation of CD4 T cell proliferation and mediated immunity (cluster #3); (ii) a positive regulation of extracellular matrix disassembly (cluster #4) that can influence and regulate the epithelial mesenchymal transition (EMT) process by altering cell–cell and cell-extracellular matrix interactions; (iii) a cellular response to prostaglandin, known to gain an immune suppressive privilege to GBM (cluster #4) (see Fig. 1B, Additional file 2: Table S7, S8).