STING1 and neoplasm: Along this line, it has been highly demonstrated that epigenetic remodeling of cancer cells of different histotypes by decitabine and guadecitabine induced/up-regulated the expression of different immune molecules (i.e., HLA class I, cancer-testis antigens (CTA), co-stimulatory molecules, interferon-stimulated genes), resulting in improved immune recognition of tumor cells [18–22].