Stemming from the results obtained, in which specific negative immune pathways, in particular the negative regulation of MHC class II antigen processing/presentation and the negative regulation of CD4 T cell proliferation, are enriched in GBM compared to MM-BM, and from the well-known immunomodulatory properties of DHA, we tested the hypothesis that epigenetic remodeling of GBM cells could render them phenotypically closer to the more immunogenic MM-BM and MM cells. The gene discussed is CD4; the disease is glioblastoma.