Initially, we found that PPP2R1B is the only gene that is both ectopically expressed in liver metastasis tissues (GSE179979) and related to patient survival in the TCGA cohort (Venn diagram, Fig. 1A), which suggests that PPP2R1B may play an important role in the metastasis of CRC. This evidence concerns the gene PPP2R1B and colorectal carcinoma.